Age Associated Decrease in Intrinsic Action Potential (AP) Firing Rate in Sinoatrial Node Cells is Linked to Deficient Intrinsic cAMP-PKA-Ca2+ Signaling
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چکیده
منابع مشابه
Impaired signaling intrinsic to sinoatrial node pacemaker cells affects heart rate variability during cardiac disease.
The normal heart beat intervals are neither strictly stationary nor completely random, and continuously shift from one period to another. Decoding the ECG identifies this "hidden" information that imparts inherent complexity to the heart-beating interval time series. Loss of this complexity in cardiovascular disease is manifested as a reduction in heart rate variability (HRV) and this reduction...
متن کاملCALL FOR PAPERS Cardiovascular and Cerebrovascular Aging–New Mechanisms and Insights Age-associated abnormalities of intrinsic automaticity of sinoatrial nodal cells are linked to deficient cAMP-PKA-Ca signaling
Liu J, Sirenko S, Juhaszova M, Sollott SJ, Shukla S, Yaniv Y, Lakatta EG. Age-associated abnormalities of intrinsic automaticity of sinoatrial nodal cells are linked to deficient cAMP-PKA-Ca signaling. Am J Physiol Heart Circ Physiol 306: H1385–H1397, 2014. First published March 14, 2014; doi:10.1152/ajpheart.00088.2014.—A reduced sinoatrial node (SAN) functional reserve underlies the age-assoc...
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The heart rate and rhythm are controlled by complex chaotic neural, chemical and hormonal networks which are not strictly regular, but exhibit fluctuations across multiple time scales. A careful assessment of the heart rate variability (HRV) offers clues to this complexity. A reduction in HRV, specifically in advanced age, is associated with increase in morbidity and mortality. Mechanisms that ...
متن کاملAge-related pacemaker deterioration is due to impaired intracellular and membrane mechanisms: Insights from numerical modeling
Age-related deterioration of pacemaker function has been documented in mammals, including humans. In aged isolated sinoatrial node tissues and cells, reduction in the spontaneous action potential (AP) firing rate was associated with deterioration of intracellular and membrane mechanisms; however, their relative contribution to age-associated deficient pacemaker function is not known. Interestin...
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Sinoatrial nodal cells (SANCs) generate spontaneous action potentials (APs) that control the cardiac rate. The brain modulates SANC automaticity, via the autonomic nervous system, by stimulating membrane receptors that activate (adrenergic) or inactivate (cholinergic) adenylyl cyclase (AC). However, these opposing afferents are not simply additive. We showed that activation of adrenergic signal...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2011
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2010.12.2561